UC San Diego Study Links Depression and Anxiety to Long COVID in Women

Older women participating in a mental health support group

San Diego, CA, January 29, 2026

A recent study from UC San Diego has found a significant correlation between mental health history and the risk of long COVID in older women. Findings indicate that women with a history of depression and anxiety have a 78% higher likelihood of developing long COVID following a SARS-CoV-2 infection. The study highlights the necessity of integrating mental health interventions to protect this vulnerable group and address ongoing health challenges resulting from pandemic-related isolation and stress.

San Diego, CA

UC San Diego Study Links Depression and Anxiety to Long COVID in Women

Research highlights critical mental health interventions

Research from UC San Diego reveals a significant correlation between mental health history and the risk of long COVID among older women. The study indicates that women with past experiences of both depression and anxiety are 78% more likely to develop long COVID following a SARS-CoV-2 infection. This important finding sheds light on the need for proactive mental health measures aimed at protecting this vulnerable demographic.

The recent analysis published in the journal Menopause on January 27, 2026, draws from data within the Women’s Health Initiative—a long-term study focused on the health of postmenopausal women across the United States. Interestingly, the research found that while the rates of infection did not differ among women with these mental health issues, their propensity for developing long COVID symptoms was significantly heightened. Symptoms such as fatigue, brain fog, and shortness of breath became more prevalent for those with elevated anxiety and stress levels, underscoring the complex relationship between mental health and the ongoing effects of COVID-19.

Importance of Addressing Mental Health

In light of these findings, the implications for public health policies are profound. The study highlights a crucial gap in mental health support that could aid older women in adhering to public health guidelines. Many individuals suffering from long-term depression or both disorders showed reduced compliance with safety measures, such as wearing masks and practicing social distancing. This raises an essential discussion point—how mental health challenges could inadvertently lead to increased infection rates and compounded health problems.

Support for Loneliness and Isolation

The research emphasizes the necessity of addressing mental wellness, particularly in times of pandemic-related isolation and loneliness. Interventions aimed at enhancing support systems for older women struggling with mental illness are vital. By fostering community engagement and providing accessible mental health resources, we can potentially lessen the long-term health impacts of COVID-19 and improve the quality of life for this at-risk group.

The Women’s Health Initiative and Its Role

The Women’s Health Initiative has been instrumental in understanding various health conditions that affect postmenopausal women. Funded by reputable organizations such as the National Heart, Lung, and Blood Institute and the National Institutes of Health, this initiative provides an invaluable resource for ongoing research, helping delineate the connections between mental and physical health among women in this age group.

Key Takeaways and Future Directions

As we look ahead, the importance of blending mental health support with physical health strategies cannot be overstated. Policymakers are encouraged to prioritize mental health care tailored for older women, ensuring that robust support is available as a preventive measure against long COVID and similar complications. This focus on integrated health approaches will not only strengthen community ties but also contribute to economic resilience by fostering a healthier, more engaged population.

Frequently Asked Questions (FAQ)

What is long COVID?

Long COVID is a chronic condition where individuals experience persistent symptoms lasting three months or more after the initial SARS-CoV-2 infection. Symptoms can include fatigue, brain fog, shortness of breath, and other health issues.

How does depression and anxiety affect the risk of long COVID in older women?

Older women with a history of both depression and anxiety have a 78% higher risk of developing long COVID after a SARS-CoV-2 infection. These mental health conditions can increase the likelihood of experiencing long COVID symptoms and may also impact adherence to public health guidelines, further elevating the risk.

What are the implications of this study for public health?

The study emphasizes the need for targeted mental health interventions for older women to reduce the risk of long COVID. Public health officials and policymakers should focus on providing support to individuals with mental health challenges to mitigate the impact of long COVID in this population.

What is the Women’s Health Initiative?

The Women’s Health Initiative is a long-term national study that began in the early 1990s, focusing on the health of postmenopausal women in the United States. It provides valuable data on various health conditions affecting this population, contributing to a better understanding of women’s health issues.

Key Features of the Study

Feature Description
Study Focus Investigating the link between mental health disorders and long COVID in older women
Key Finding Older women with both depression and anxiety have a 78% higher risk of developing long COVID after a SARS-CoV-2 infection
Published In Journal Menopause, January 27, 2026
Data Source Women’s Health Initiative, a long-term national study focusing on postmenopausal women’s health
Implications Highlights the need for targeted mental health interventions to reduce the risk of long COVID in older women


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